北京索萊寶科技
專注于生物學試劑及試劑盒領域
服務熱線：18101056239
專注于生物學試劑及試劑盒領域
服務熱線：18101056239
產品型號：K106525P
更新時間：2022-08-15
廠商性質：生產廠家
訪 問 量 ：1024
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產品分類
Anti-GRP78 Polyclonal Antibody
| 英文名稱 | Anti-GRP78 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | BIP;GRP78;HEL-S-89n;MIF2 |
| 應用 | WB IHC |
| 稀釋比例 | WB 1:2000-5000.IHC 1:50-200. |
| 交叉反應 | Human Mouse Rat |
| 蛋白分子量 | 70kDa |
| Gene ID | 3309 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human GRP78 |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human GRP78 |
| Subcellular Locations | Cytoplasm Endoplasmic reticulum lumen Melanosome |
| Swiss Prot | P11021 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. |
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